EFFECTS OF EXPOSURE TO A GLYPHOSATE-BASED HERBICIDE ON MALE MICEREPRODUCTION
Abstract
Glyphosate is classified as a post-emergent herbicide with a broad spectrum of activity and is the most widely sold pesticide in
Brazil and globally. Glyphosate is also recognized as an endocrine disruptor capable of inducing reproductive disorders in
animals. Therefore, this study aimed to evaluate the effects of a glyphosate-based herbicide (Gliz 480 SL) on the reproductive
function of male mice during different exposure periods. The following parameters were analyzed: testicular germinal
epithelium, daily sperm production, and sperm transit time through the epididymis. A total of 48 adult Swiss mice were divided
into three groups exposed to glyphosate at a daily dose of 0.35 mg/kg for 15, 30, or 60 days, and three control groups that
received only water (vehicle). A reduction in the relative mass of the caput/corpus of the epididymis, accompanied by a shorter
sperm transit time, was observed after 15 days of exposure, resulting in increased sperm accumulation in the cauda epididymis.
Stages V–VI of spermatogenesis showed reductions during 15 and 60 days of exposure. Based on the applied protocol, the
glyphosate formulation Gliz 480 SL can alter reproductive parameters, particularly during short exposure periods.
Downloads
Published
Issue
Section
License
A revista se reserva o direito de efetuar, nos originais, alterações de ordem normativa, ortográfica e gramatical, com vistas a manter o padrão culto da língua, respeitando, porém, o estilo dos autores.
As provas finais serão enviadas aos autores.
Os trabalhos publicados passam a ser propriedade da revista. As opiniões emitidas pelos autores dos artigos são de sua exclusiva responsabilidade.
