Bactericidal action of ABO isoagglutinins at different dilutions of anti-ABO antibodies

Abstract

In view of the big polymorphism of the blood group systems and that the hypothesis to explain them is the co-evolution with pathogens, this research had as its objective to evaluate the bactericide action in vitro of the anti-ABO antibodies upon the Escherichia coli bacteria. It was observed a substantial difference in the bacterial growth (p<0,0001) in the comparisons of Group O, Group A, Group B, and Group AB when compared to the Positive Control, demonstrating the bactericide effect of the anti-ABO antibodies. There was no significant difference (p > 0,05) between the blood systems O, A, B, and AB. Although there was no statistical difference (p > 0.05) between blood groups O, A, B and AB, blood group AB had less bactericidal action. Based on the bactericidal action of anti-ABO antibodies, these can be used in the future as non-pharmacological alternatives to help with sepsis clinical conditions.